They made their spot in the quarter-final against France.
Cavani got his second and the decisive goal with an exquisite finish as he opens up his body and struck the ball with his right foot.
The Atlético Madrid star has been involved in all four of France's games at the World Cup this summer, scoring in their first match against Australia and most recently in a thrilling win over Argentina, with both goals coming from the penalty spot.
Both Brazil, Belgium battling bad vibes
But, Axel Witsel's presence in midfield is vital, meaning Mertens remains the only expendable player in attack. They've only gone out twice at this stage in that run (vs France in 2006 and vs the Netherlands in 2010).
Ultimately, Uruguay were able to tempt Portugal into taking shots from distance and then smother them, blocking eight of the 20 Portuguese efforts on goal.
Uruguay's Luis Suarez controls the ball during the group A match between Uruguay and Russia at the 2018 soccer World Cup at the Samara Arena in Samara, Russia, Monday, June 25, 2018. "That is the way that we see football", he said.
In FIFA World Cup, the Round of Sixteen is beginning from today.
Earlier, Portugal coach Fernando Santos said he hoped Ronaldo would remain part of the global set-up.
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Cavani injured is a national disaster.' Uruguay coach Oscar Tabarez confirmed on Saturday night that Cavani was injured. "We have many young players who desire to achieve team success", he said.
"It was hard", he continued. "It was hard. Portugal had more possession and were often in our half of the pitch, and it would have been better for us to have more of the ball and play the game closer to their goal. But we have a very strong team in terms of our mindset". "They've shown throughout the World Cup how good their game is, their speed, how compact they are, it's unbelievable". Obviously I'm very happy for (Cavani's) goals and that they helped us win. It will be very hard for us.
Despite the five-time Ballon d'Or suggesting he'll remain at the highest level into his 40's, his post-match comments sparked rumours he may end his 15-year career with A Seleção das Quinas.
Gareth Southgate: Young England side 'hungry' to go as far as possible
A re-worked version of the song with new lyrics for the 1998 World Cup , Three Lions '98, spent three weeks at the summit. England had already waited too long to win on penalties.