Ronaldo played a pivotal role in France during Portugal's triumphant campaign two years ago, and during the tournament in Russian Federation he became Europe's top worldwide goal-scorer and only second in the world to Iran's Ali Daei. He combined with Luis Suarez to compete a series of precision passes to give Uruguay the early advantage with a header in the seventh minute.
Former Real Madrid ace, Pepe equalised for Portugal in the 55th minute, while Cavani got the victor seven minutes later.
Cavani now has three goals at the World Cup, but limped off in the 70th minute with an apparent injury and had to be replaced.
But on Saturday, it was Edinson Cavani who scored twice to earn victory for the Uruguayans.
Soccer Football - World Cup - Round of 16 - Uruguay vs Portugal - Fisht Stadium, Sochi, Russia - June 30, 2018 A photographer captures Portugal's Cristiano Ronaldo as he looks dejected while he walks off the pitch after the match.
DeAndre Jordan Opts Out of Deal with Los Angeles Clippers
The Clippers traded Blake Griffin to the Detroit Pistons last winter and Chris Paul to the Houston Rockets last summer . And when news broke around midnight Saturday that Jordan will (hopefully) sign with Dallas, Twitter did not disappoint.
Uruguay's formidable defence have not let in a goal at all in 2018, while Suarez has recovered from a poor first outing in Russian Federation to score in wins over Saudi Arabia and the hosts.
"It's not the time to talk about the future when it comes to the players and coach", the Portugal captain said.
Ronaldo had one clean shot the entire 90 minutes and it came in the opening moments of the match, directly into the arms of Uruguay goalkeeper Fernando Muslera.
Ronaldo and co tried hard but it ultimately proved to be impossible to breach Uruguay's famed defence twice. He also joined Pele, Miroslav Klose and Uwe Seeler as the only players to score in four World Cups.
Central defenders Diego Godin and Jose Gimenez play their club football together at Atletico Madrid and that showed as they repelled nearly everything Portugal could throw at them with superb anticipation and understanding. Ronaldo ran in front of Pepe and drew the attention of both Gimenez and Godin.
LeBron James bound for Los Angeles Lakers
As the Cleveland Cavaliers found out the hard way, it takes more than just LeBron James to dethrone the Golden State Warriors . And while he has always been compared to Michael Jordan, Johnson is the one whose game more closely resembles his own.
Not only did the South Americans let one in but it was a corner from a header considering Diego Godin and José Giménez are their two centre backs, and hadn't conceded a goal in the tournament before Pepe's equaliser, it was quite the surprise.
Being level lasted only seven minutes.
Cavani's second goal was another magnificent effort as he met Bentancur's pass first-time and curled the ball into the net from the edge of the penalty area. "That was an incredible play, they have never scored like that before", the 63-year-old said, ruefully.
Ronaldo had company everywhere he went on the field and Portugal's supporting cast was unable to provide enough help.
Brazil fans hold funeral for Germany after Russian Federation 2018 elimination
Speaking immediately after Germany's shock World Cup exit, manager Low said: 'The disappointment of being eliminated is just huge. Finally, former German worldwide Dietmar Hamann believes Germany didn't deserve to get through the group stages.