This time the Court Philippe Chatrier crowd - at least the ones that could be prised away from their luncheon - got a match, if not a contest, as Muguruza roared to a 6-2 6-1 victory and on to a semi-final against top seed Simona Halep in which the world number one ranking will also be on the line.
The Romanian is chasing a first Grand Slam title having lost the final of this event a year ago to Jelena Ostapenko.
Garbine Muguruza gave Maria Sharapova no chance in their quarterfinal. She made decent inroads in the tournament that turned her away previous year but clearly viewed it as incremental progress after a flat, straight-sets loss to Spain's ascendant Garbine Muguruza.
After making 30 unforced errors in the first set, which she lost 7-6 (2), Halep finally found the right rhythm to dictate points with deep groundstrokes and aggressive returns.
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Romania's Simona Halep came from a set down to beat Angelique Kerber in 2 hours 14 minutes.
Halep has won five of her past nine matches against the 12th-seeded Kerber, including their most recent encounter in the Australian Open semifinals when she saved two match points.
"I have just to stay strong, to try to make her uncomfortable on court and to try to play my game", Halep said. "So I think that's why I won today", Halep said.
Sharapova didn't play a point in the fourth round, because Serena Williams pulled out of their much-anticipated showdown with an injured chest muscle.
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On Court Suzanne Lenglen, Marin Cilic and Juan Martin del Potro were locked in a first-set tiebreak when play was called off.
Nadal was broken three times and lost the opening set of his quarterfinal Wednesday against 11th-seeded Diego Schwartzman of Argentina by a score of 6-4.
The signs were ominous when the five-times Grand Slam champion coughed up three nervy double-faults in the opening game.
Muguruza was punishing the former world number one's second serve and broke again at the start of the second set, and although this time Sharapova hit straight back. Muguruza won the French Open in 2016, then Wimbledon a year ago. Sharapova was the French Open champion in 2012 and 2014; Muguruza took the trophy in 2016. "She had a lot more depth in the ball". "My head won it". Muguruza is 3-0 in career grand slam semifinal matches. She went on to commit only 16 errors over the course of the next two, which was the difference in getting the win. Some of those matches were very defining for me.
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One could not tell on Monday, however, as she kept misfiring against two-time Grand Slam champion Kerber.