Detroit took two of three in the series, and the three games were played in just under 24 hours. The Mariners (22-17) have looked like contenders for their first postseason spot since 2001, but losing Cano for an extended period would obviously hurt.
The Tigers lead the Mariners 3-2 in the bottom of the seventh.
Robinson Cano's three-run homer helped the Mariners earn a doubleheader split. "Everyone knows what he means to this team, and he's down right now, but we have other guys who can step up".
Hamburg fan protest: Chaotic scenes as flares stop game, massive police response
Elsewhere, Hoffenheim and Borussia Dortmund joined Schalke and champions Bayern Munich in the league's top four. Hamburg got off to the ideal when Aaron Hunt gave the hosts a 1-0 lead after 11 minutes.
Tigers right fielder Niko Goodrum, playing for an injured Nicholas Castellanos, led off the fifth inning with a solo home run.
Then Goodrum singled past diving Ryon Healy down the first base line, allowing Jones to reach third with no outs. "We had a miscommunication over the phone about it and I'm not going to point fingers". Detroit broke a 1-all tie in the sixth against Seattle starter Marco Gonzales (3-3).
Cano was batting in the top of the third inning when a pitch from Detroit left-hander Blaine Hardy sailed inside and hit him near the hand.
Man City boss Guardiola desperate to keep Aguero from Atletico Madrid return
Pep Guardiola has vowed to give Phil Foden or Brahim Diaz his Premier League winner's medal if they end up without one. He said: "I say not too much, maybe players want to play more and want to leave, but not too many.
Taking the hill for the Mariners will be James Paxton and he has gone 2-1 with a 3.40 ERA and a 1.13 WHIP in eight starts on the year, including 1-0 with a 3.30 ERA and a 1.07 WHIP in five starts on the road.
Dee Gordon grounded out to first to end it.
"It needed to be challenged after the fact when I saw it", said bench coach Manny Acta, who was filling in for Scott Servais as Seattle's manager.
Washington Capitals vs. Tampa Bay Lightning, 5-13-2018 - Expert Prediction
Nashville and Winnipeg will decide the final third-round team Thursday in Game 7 of their Western Conference second-round series. Barry Trotz's Capitals took a 1-0 series lead Friday, as they scored the first four goals in a 4-2 victory at Amalie Arena.
The Mariners activated right-hander Dan Altavilla from the 10-day disabled list before the second game. Jose Iglesias hit a two-run homer for the Tigers, and Grayson Greiner contributed the first two RBIs of his big league career.