It was virtually the final touch of a magnificent campaign which saw City end the season with a record 16 away wins and 106 Premier League goals.
Manchester City trailed for a total of just 153 minutes in Premier League matches this season - the fewest by a side in a single campaign.
Saints looked to have secured the draw but, with virtually the final kick of the game, Jesus produced a flawless lobbed finish to spark wild City celebrations.
And now Sky Sports have captured Pep Guardiola side's dominance on English football this season with a brilliant info-graphic, highlighting all the records that the side have broken this season.
Storms not expected tonight
Sunday , the high will be near 91 with partly sunny skies, and a south wind of 6 to 10 miles per hour , the weather service said. After some thunderstorm activity Friday night , the weather remains a bit unsettled over the next few days.
Opposition striker Jesus broke free towards goal and lofted the ball over the stranded Alex McCarthy with the last kick of the game to send his team to 100 points, but ultimately the mood wasn't dampened after another passionate display from Hughes' men.
"I think [Virgil] van Dijk has helped them a lot to be more consistent in the defensive department, especially in the box, and (there is) the quality up front and the quality in the way they play".
The old record was held by Liverpool, who collected 98 points in the 1978-79 season (adjusted to three points for a win).
Manchester City star midfielder, Kevin De Bruyne, has won the maiden Cadbury playmaker of the season award.
"I need to give myself a shake because I'm a little bit flat because I felt we should have won this game against the champions", said Hughes, after City had beaten Saints with an injury-time goal for the second time this season.
Man United beat City to top of Premier League table
Manchester City manager, Pep Guardiola has disclosed the club's transfer plans for next season. City are obvious favourites to win the game at their best odds of 4/9 at BetVictor.
"Numbers are numbers, they are the outcome of the way we played".
But they had no intention of letting the impending party distract them on the south-coast. Dusan Tadic's corner was flicked goalwards by the head of Maya Yoshida, but Claudio Bravo produced a good save to keep it out.
Swansea City have been relegated after seven years in the Premier League.
Extending that form out over the course of 38 games is now the challenge for the German to deliver a first league title since 1990.
The Buttler did it as Royals stay alive in IPL
For Rajasthan, Archer bagged couple of wickets but leaked 42 runs while Sodhi scalped one conceding 29 runs. All told, he took 31 runs off 14 balls from Kaul at a strike-rate of 221.42 and a control percentage of 85.