The Freiburg team eventually emerged back onto the pitch, where Winkmann explained to a bemused Streich that it was a penalty for the home side.
After finally getting their half-time break, the players were forced to wait again for the second half after Mainz fans threw hundreds of rolls of toilet paper onto the pitch in protest against Monday night games.
There were weird scenes in the Bundesliga on Monday as Mainz and Freiburg players returned to the pitch so a penalty could be taken before half-time.
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After a lengthy delay, Pablo De Blasis stepped up to take the spot-kick for Mainz, beating Alexander Schwolow in the seventh minute of stoppage time to open the scoring for his side.
Following a nervy first half Mainz took the lead in curious circumstances when they were given a penalty by Video Assistant Referee system VAR after the referee had already blown for half-time. One Freiburg player could even be heard saying: "No, we're not coming back out".
De Blasis added a lucky second as his shot rolled over the line after hitting the inside of the post, with Schwolow out of his goal having passed the ball straight to Mainz midfielder Robin Quaison.
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The game itself may have been otherwise unremarkable, but that didn't stop the fans from creating a spectacle of their own as they continued to display their displeasure with Monday night games.
De Blasis scored a second on 78 minutes to secure victory, taking Mainz above Freiburg on goal difference and eight points clear of automatic relegation, while putting the visitors into the relegation play-off spot in 16th.
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