Trump said the USA was prepared to sustain economic, diplomatic and military pressure on Assad until he ends what Trump called a criminal pattern of killing his own people with internationally banned chemical weapons. UK Prime Minister Theresa May admitted there was "no alternative path" while French president Emmanuel Macron tweeted that a "red line has been crossed" by Syrian leader Bashar al-Assad.
Justifying the decision to mount air strikes against Syria the three governments laid out evidence that the regime had used chemical weapons in the attack earlier this month, which opposition activists, rescue workers and medics say killed more than 40 civilians.
The three strikes targeted a research center in Damascus, a chemical weapons storage facility west of Homs, and a chemical weapons equipment storage facility and command post near Homs.
Pentagon spokeswoman Dana White warned that Russian Federation was actively attempting to sow confusion about the attack. "Initial indications are that we accomplished the military objectives without interference from Syria", he said.
"There have been many instances when we have seen them using those chemical weapons".
United States President Donald Trump agreed to launch coordinate strikes against Syria with allies on Friday. U.S., British and French attack aircraft, including two U.S. Air Force B-1B strategic bombers, launched advanced missiles from outside Syrian airspace, officials said.
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Douma and the sprawling eastern Ghouta region near the capital, Damascus, had been under rebel control since 2012 and was a thorn in the side of President Bashar Assad's government for years.
He added that the United States had no option but to orchestrate such an "ineffective" attack, which he noted would fail to have any impact on the fight against terrorism in Syria. "We thank them both".
With more than 100 missiles fired from ships and manned aircraft, the allies struck three of Syria's main chemical weapons facilities, U.S. Defense Secretary Jim Mattis and Joint Chiefs of Staff Chairman General Joseph Dunford said.
"Clearly the Assad regime did not get the message a year ago".
The defense secretary said on Thursday that he favored a measure response aimed at chemical weapons facilities, and did not want the U.S.to become more deeply involved in a complicated, many-sided conflict.
Scottish first minister Nicola Sturgeon condemned the attacks and accused May of "complying with presidential wishes", while Lib Dem leader Vince Cable warned: "Riding the coat-tails of an erratic United States president is no substitute for a mandate from the House of Commons".
The sites were chosen to minimize civilian loss of life and possible release of chemical agents, the Pentagon officials said.
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Several missiles hit a research centre in Barzeh, north of Damascus, "destroying a building that included scientific labs and a training centre", SANA reported.
"The Russian disinformation campaign has already begun".
Mattis said he was not aware of any USA losses, and added, "Right now we have no additional attacks planned".
He added that none of America's aircraft or missiles were "successfully engaged" by the Syrian regime and noted that this strike was twice the size of the strike previous year.
The U.S. has about 2,000 troops in northeastern Syria, where they have partnered with Kurdish fighters to dismantle the Islamic State.
Putin responded to Saturday's attack by calling the strikes "an act of aggression against a sovereign state that is at the forefront of the fight against terrorism". Mattis estimated the latest air campaign was about twice the size of the 2017 strike.
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