Should OM win past RB Salzburg, they will earn a place in the UEFA Europa League final at the Groupama Stadium in Lyon, taking on the victor of the other semi-final, between Arsenal and Atletico Madrid.
The other semi-final will be between French club Marseille and Austrian outfit Salzburg, who advanced following fine comeback wins over RB Leipzig and Lazio respectively.
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Atletico also beat Liverpool in the Europa League semi-finals in 2010 before going on to lift the trophy.
The Gunners came from 2-0 down to draw the second leg of their quarter-final at CSKA Moscow 2-2 on Thursday night, progressing 6-3 on aggregate against the Russian side.
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The Gunners, now sixth in the Premier League, host Diego Simeone's side on April 26 before the second leg at the Wanda Metropolitano Stadium on May 3.
Marseille are unbeaten at home in this season's Europa League and will have the backing a fanatical crowd when they host Salzburg in the first leg.
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Because of injuries and trades, Lue has been forced to shuffle his lineups all season, and the postseason will be no different. And why not, The Monster will get the benefit of the doubt on ever whistle and he is still the best player in the world.
He could have a key role to play as the battle continues to book a place in the final at Lyon's Groupama Stadium on May 16.