The Palestinian Authority has accused militants in Gaza of trying to kill Hamdallah.
It is Hamdallah's second visit to the Gaza Strip since the signing of an Egyptian-brokered "reconciliation" agreement between the West Bank's governing Fatah faction and Gaza's Hamas rulers late past year.
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Palestinian Prime Minister Rami Hamdallah on Tuesday escaped unhurt after an explosion targeted his convoy when it entered the Gaza Strip. He said in the address that three cars were damaged.
The Gaza-based terrorist group also condemned the attempt to harm the security of the Gaza Strip and thwart attempts to achieve Palestinian reconciliation. No one was injured and security services had begun an investigation, ministry spokesman Eyad Al-Bozom said. Gunfire was reported shortly after the explosion.
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A statement on official Palestinian media said president Mahmoud Abbas considered it a "cowardly targeting" of Hamdallah's convoy and held Hamas responsible.
The official Wafa news agency said eight people were injured after an explosive device was detonated as the convoy was moving in Beit Hanoun in northern Gaza Strip.
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Hamas has ruled Gaza since it ousted the Fatah-led PA in 2007.