The victims include students and adults, according to the Broward County Sheriff Scott Israel.
Cruz was later arrested without incident.
The gunman, identified as 19-year-old Nikolas Cruz, a former student of the school, has been taken into custody.
Israel said that Cruz had an AR-15 type weapon, and countless magazines in his possession.
On Wednesday the images from a helicopter show students running for their lives, ditching their backpacks and hands over their heads. Rescuers also appeared to be setting up a triage unit in a tent outside the school.
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"When I was at the hospital with the victims, with the victims' families, over and over again what they said to me in Texas - they said gun control is not the answer here", Cruz said.
Trump said he has spoken with Florida Gov. Rick Scott about the shooting. "It's a horrific situation", Broward Country Schools Superintendent Robert Runcie told reporters.
The FBI is assisting local officials in the investigation.
An ex-classmate and former teacher told ABC News that before Cruz was expelled from the school he was barred from carrying a backpack on campus.
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In a statement issued by the Foreign Ministry, Egypt shares sympathy to the USA administration and the families of the victims.
Many students thought it was a drill because a fire alarm practice had taken place earlier that day, but then heard the sound of shooting.
Story Developing. Stay with ABC Action News for updates.
Authorities apprehend student after lockdown at Loch Raven High School
Meanwhile, police directed concerned parents to a staging area at Rock City Church at 1607 Cromwell Bridge Road. Thursday morning that they had found a student in possession of a firearm at the school.