Jeff Flake, a vocal Trump critic who said he will not seek re-election this fall.
The Air Force colonel and first female fighter pilot in that branch of the military is now serving her second term in the House Representatives.
The Arizona election will showcase the explosive feud between the Republican Party's establishment and its hardline anti-immigration wing - all in a border state that features the nation's fourth largest Hispanic population. McSally also told GOP politicians to "grow a pair of ovaries".
McSally refused to condemn Trump's vulgar description of African countries during a meeting, saying she, too, can "speak a little salty behind closed doors at times".
"I'm a fighter pilot and I talk like one", she says. "As of today, I am a candidate for the office of United States senator from Arizona".
Rescue Crews Make Their Way Into Worst-Hit Mudslide Areas
Mr Brown said the amount of debris is making it hard for rescue crews to reach people trapped in their homes. Before the storm there were widespread evacuations in and near the mammoth Thomas Fire burn scar.
McSally also compared her own political style to the president, saying in her announcement video, "Like our president, I'm exhausted of PC politicians and their BS excuses".
Campaign staff for Ward, who also has been praised by Trump, released a statement Tuesday welcoming Arpaio to the race, a development the campaign said reflects conservatives' distrust of official Washington.
She co-sponsored an immigration plan considered a conservative wish list of sorts released by House conservatives this week that would reduce legal immigration levels by 25 percent, block federal grants to sanctuary cities and restrict the number of relatives that immigrants already in the US can bring here.
But in a sign of how thoroughly Trump now dominates her party, McSally has been snuggling up to the 45th president in preparation for her Senate run. The bill, which is unlikely to survive the GOP-controlled Senate, also provides temporary legal status for young immigrants enrolled in the Deferred Action for Childhood Arrivals, or DACA, program.
NWS: Winter Storm Warning Thursday Night, Friday
A total of one-tenth of an inch of ice, and snow and sleet accumulations of 3-7 inches are possible by Saturday morning. Temperatures well into the 60s Friday evening are predicted to fall to near freezing Saturday morning.
"Like in almost every other state facing a Senate election this cycle, the Arizona Republican primary will be nasty, expensive and very long", David Bergstein, a Democratic Senatorial Campaign Committee spokesman said Friday in a written statement.
"It does not matter what we say about education, jobs or the economy", the RNC wrote, "if Hispanics think we do not want them here, they will close their ears to our policies".
"I absolutely refused to bow down to Sharia law".
Ward unsuccessfully launched a primary campaign in 2016 against Sen. "After eight years of fighting, I won my battle for the religious freedom of American servicewomen".
And though Senate Majority Leader Mitch McConnell - the epitome of the Republican establishment who is hated by some on the far right - has called her one of his top recruits this election cycle, McSally gives D.C. Republicans a rhetorical pounding in the video. "It will drain the GOP's resources, demoralize their voters, and expose the flaws in each of their candidates".
You are only making America white again - Mahama jabs Trump
Day event in the Roosevelt Room, a reporter directly asked Trump to face up to his comments , the Hill reported . Trump tweeted Friday morning that he used " tough " language at the meeting, but not the reported vulgarity.