MI once led by 19 points (36-17) during the first half, but was outscored 54-26 throughout the rest of the game.
Mo Wagner led the Wolverines with 14 points and nine rebounds, while Muhammad-Ali Abdur-Rahkman and Zavier Simpson each had 11 points.
The Wolverines (7-3, 1-1 Big Ten) led 43-30 at the half with six different players hitting a 3-pointer, and Wagner hitting 2 of 3 attempts.
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After Michigan dominated and put on a clinic much of the first 20 minutes of the game, it looked like the Wolverines were going to run away with a convincing victory until Ohio State used a 16-0 run that started at the end of the first half and carried into the second half to wipe out the deficit.
"I think we've made some improvements in some areas, and I think maybe as important as anything is our players have been able to see success", Holtmann said after being MI.
MI led 43-30 at the half with six different players hitting a 3-pointer, and Wagner hitting 2 of 3 attempts. "We just did not play well in the second half". The Buckeyes took over after that.
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Holtmann, the Buckeyes' first year coach, got a taste of the Ohio State-Michigan rivalry. MI led by as many as 20 in the half, but the 7-0 run - capped by a monster dunk by JaeSean Tate - pulled it closer.
"It was just a lack of focus and sense of urgency coming out of the half", Robinson said.
Ohio State: The Buckeyes came on strong and played stout defense to roar back and flatten their rival. Ohio State actually projects him to cornerback and he can also provide some special teams value immediately in the return game. He finished with three points.
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On Tuesday, five-star defensive back Tyreke Johnson (6-foot-1, 191 pounds, Jacksonville, Fla.) announced via video with 247Sports that he had committed to Ohio State.