Financials were also pressured, with the sub-index edging down 0.57 percent.
"A benign outcome for equities would be the Fed going somewhere in between being too passive on reducing its bond holdings and too aggressive in hiking interest rates", said Soichiro Monji, chief strategist at Daiwa SB Investments in Tokyo. Investors, however, awaited details on how the central bank will unwind its United States dollars 4.5 trillion balance sheet.
The financial markets will also sift through the "dot plot" representing Fed policymakers' rate projections for any hints of a rate hike in December.
Manchester United and Marcus Rashford allow Burton little consolation
The Manchester United manager is the joint-record holder with Sir Alex Ferguson and Brian Clough on four League Cup triumphs. Mourinho said "Romero played the Europa League final, which was the game of the season for us and he is not playing".
According to CME FedWatch, markets are pricing in a more than 50 percent chance of a Fed hike in December, up from around 31 percent as recently as September 8.
"We continue to expect that the ongoing strength of the economy will warrant gradual increases in that rate to sustain a healthy labor market and stabilize inflation around our 2 percent longer-run objective", Chair Janet Yellen said during a press conference. Lien cited softer wage growth, employment and spending since the central bank's last policy meeting, adding that there was "very little to be excited about" regarding the U.S. economic outlook. There was little follow-through from U.S. President Donald Trump's bellicose rhetoric over North Korea on Tuesday.
The rose 0.47%, while Australia's fell 1.09%. In his remarks, Trump called North Korean leader Kim Jong Un a "Rocket Man" on a "suicide mission" and said the US would have to "totally destroy" the hermit state if forced. More recently, the North launched a missile that passed over Japan on September 15 local time. The U.S. data storage company, which is involved in joint ventures with Toshiba, had been part of another group that had attempted to buy the Japanese conglomerate's flash memory unit. Toshiba stock was up 0.32 percent in early trade. It's set to make its interest rate decision on Thursday. Japan's Nikkei closed up 0.05 percent and Shanghai added 0.3 percent.
Apple is slipping after disappointing reviews of the new Apple Watch (AAPL)
Here's the part where I get really honest with you and say this: This cellular capability is enough to convince me to upgrade. While Samsung did have a smartwatch with a modem in it, I could never get it to work well and this model never caught on.
"Hurricanes Harvey, Irma and Maria have devastated many communities, inflicting severe hardship", the Federal Open Market Committee said in its statement on Wednesday following a two-day meeting in Washington.
On the energy front, oil prices rose after declining slightly overnight.
Brent crude futures were up 0.3 percent at $55.30 a barrel and US crude rose 0.6 percent to $49.76 a barrel.
No evidence to link London attack directly to militant groups - United States sources
Islamic State extremists have claimed responsibility but British officials have said they don't see proof of a connection yet. Metropolitan Police Commander Dean Haydon said: "This continues to be a fast-moving investigation".
Gold edged up 0.1 percent to US$1,313 an ounce as the dollar dipped.